The lumps become smaller after neoadjuvant therapy for breast cancer can not be avoided, and it is suggested that patients can take surgical treatment after neoadjuvant therapy. Neoadjuvant therapy for breast cancer patients refers to systemic chemotherapy before treatment, which can make the tumor tissue shrink, improve the success rate after surgery, and control the tumor metastasis and spread. However, the cancer cells have not completely disappeared after the lumps become smaller after neoadjuvant therapy, and then surgery is needed to completely remove the tumor tissues. Depending on the specific conditions, breast cancer patients after neoadjuvant therapy can be treated with breast preservation surgery, total mastectomy, radical surgery and extended radical surgery. Breast cancer patients also need to take surgical treatment after the breast lump becomes smaller after neoadjuvant therapy. Patients are advised to seek medical treatment in time, and can follow the doctor’s advice to choose the appropriate measures for treatment. In addition, patients should seek regular medical attention to monitor their condition.