The difference between fenbufen and ibuprofen is as follows:1. Fenbufen: Fenbufen is a long-acting non-steroidal anti-inflammatory drug, mainly through the inhibition of cyclooxygenase activity so that the synthesis of prostaglandins is reduced to play an anti-inflammatory and analgesic role, the clinical mainly used in rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, spondyloarthralgia and other treatments, but also can be applied to endodontic inflammation, maxillofacial trauma, pain after tooth extraction.2, Ibuprofen: Ibuprofen is more commonly used non-steroidal anti-inflammatory drugs, belonging to the medium-acting analgesic, clinically used to relieve mild or moderate pain, such as headache, migraine, toothache, periodontal infection caused by swelling and pain, etc., the common cold accompanied by fever can also be applied to reduce fever.