Indirect bilirubin over 20 umol/L is considered abnormal, and if the elevation is more than 1.5 times higher, i.e., 30 umol/L, it is of some severity. Treatment is needed to address the cause. 1. The normal reference range of indirect bilirubin is 1-20umol/l. When red blood cell destruction exceeds the metabolic capacity of the liver, indirect bilirubin is not glucuronidated in the liver, resulting in elevated indirect bilirubin. For example, when blood type incompatibility is transfused, hemolysis is triggered in patients, and a large number of red blood cells in the body are destroyed, resulting in high indirect bilirubin in the blood. 2. When indirect bilirubin is elevated, it should be combined with other test results, such as total bilirubin and routine blood tests, to determine the possible causes of the disease. When the indirect bilirubin is high, if the total bilirubin is >34.2umol/L, it suggests hepatocellular necrosis, which is mainly related to viral hepatitis, cirrhosis, primary liver cancer and other liver diseases. 3. In the case of significantly elevated indirect bilirubin with hemoglobin, if the red blood cell count is significantly decreased and a large number of red blood cells are destroyed, it may be related to leukemia, hemolytic anemia, aplastic anemia and other blood system diseases. When indirect bilirubin is elevated, it is recommended to consult a doctor in time, and combine with relevant examinations under the doctor’s guidance to clarify the cause of the disease, so as to avoid delaying the condition.