Omeprazole, lafutidine are acid inhibitors, the two have different mechanisms of action, generally omeprazole side effects are smaller. Omeprazole is a proton pump inhibitor, when the patient has gastritis, gastric ulcer, reflux esophagitis and other digestive system diseases, the patient will selectively apply omeprazole and other acid inhibitors to inhibit the secretion of gastric acid and reduce gastric discomfort, but the long-term application of omeprazole will appear liver and kidney function damage, diarrhea, vomiting and other adverse reactions occur. Lafutidine is an Hâ‚‚ receptor antagonist, which promotes ulcer repair by inhibiting gastric acid secretion, but long-term application will also damage liver and kidney function, palpitations, diarrhea, dizziness, fatigue and other adverse reactions. Both have different mechanisms of action, but both have adverse reactions, and Lafutidine side effects are more common. The above drugs should be used under the guidance of a physician and in accordance with the doctor’s instructions, and should not be treated by self-determination.