The possible causes of twitching and jumping of the upper lip are habitual twitching, facial muscle spasm, Parkinson’s disease, hypocalcemia, etc.: 1. Habitual twitching: mostly seen in children, easy to appear when the pressure of study is too great, too nervous, try to rest more and adjust the emotional state, usually will be relieved after rest; 2. Facial muscle spasm: patients will have intermittent involuntary clonic twitching of one side of the facial muscles or Painless tonicity, mostly due to abnormal artery or vein aneurysm, brainstem infarction and other reasons, resulting in ectopic excitation of facial nerve or pseudo-synaptic conduction with twitching and jumping performance. The early onset is intermittent twitching of the orbicularis oculi muscle, after which it gradually spreads to other facial muscles on one side of the face, mainly with twitching of the orofacial muscles, but also with twitching and jumping of the upper lip; 3. Parkinson’s disease: generally seen in the elderly, with uncontrolled twitching and trembling of the lips, accompanied by resting tremor and slow action; 4. hypocalcemia: low calcium can lead to increased neuromuscular excitability and the appearance of local muscle tremors symptoms. If it is the first time to find the upper lip twitching and jumping, it is recommended to first pay attention to rest and observe, if it continues not to improve need to be alert to the disease factors caused by the twitching, it is recommended to promptly go to the hospital for examination to clarify the cause, and then targeted treatment.