The five-year survival rate for stage III papillary thyroid cancer is more than 50 percent. Stage III thyroid cancer is defined as a thyroid cancer that is larger than 4 centimeters in size with regional lymph node metastasis. Papillary thyroid cancer belongs to a kind of thyroid cancer with relatively low malignant degree. Although lymph node and distal organ metastasis and proliferation have occurred in stage III, as long as timely surgery, targeted therapy and immunotherapy are adopted, the cure rate is still good, and the five-year survival rate can reach more than 50%, and the survival cycle of some patients will even be longer. The survival period of papillary thyroid cancer is related to the tumor size, patient’s gender, patient’s age, extra-glandular infiltration, distant and lymph node metastasis, cell type, and treatment. Therefore, the survival time of stage III papillary thyroid cancer is still good as long as it is actively treated under doctor’s guidance, so remember not to give up.