High immunoglobulin A is caused by autoimmune imbalance, which occurs in common diseases such as liver insufficiency, hepatic hypoplasia, or chronic liver hyperplasia, as well as cirrhosis of the liver. In addition, when immunoglobulin A is high, it also proves that the body has some immune diseases, such as rheumatism, rheumatoid arthritis, liver syndrome, or systemic lupus erythematosus, which can cause some changes in immunoglobulin. Finally, high immunoglobulin A can also occur in the presence of skin diseases, such as acute eczema and acute urticaria, which also have the above clinical symptoms and changes.