After the drug-resistant of triple III, the therapeutic drugs should be changed under the guidance of the doctor. When replacing therapeutic drugs after drug resistance, it is necessary to evaluate various situations, such as the patient’s age, the presence of underlying diseases, history of medication, etc. Therefore, under the guidance of a professional hepatologist, the medication regimen should be adjusted, and self-adjustment of medication should not be allowed, not to mention unauthorized discontinuation of medication. If virus drug resistance occurs, some patients will have anorexia, fatigue, and even jaundice, but most patients only have slight fatigue and weakness, which is easy to be ignored. However, when the virus develops drug resistance, the first thing that will happen is the rebound of the viral load, which can be detected by the DNA test of hepatitis B virus. Therefore, abnormalities can be detected in time through regular review and corresponding adjustments can be made to the medication regimen as soon as possible in order to minimize liver cell damage. Hepatitis B triple positive patients should have regular outpatient follow-ups, and if drug resistance occurs, after the doctor changes the medication regimen, they should strictly follow the doctor’s instructions to take the medication, and should not omit to take the medication, or take less medication, so as to avoid drug resistance again. If there is any discomfort during the period, the patient should also be timely rechecked.