The main effects of splenectomy in cirrhosis include markedly elevated platelets and the development of infections. 1. Significantly elevated platelets. Cirrhosis requiring splenectomy is usually due to hypersplenism. Some patients with liver cirrhosis will experience a sharp rise in platelet count after surgery, which may induce thrombosis. At this time, you need to take the appropriate amount of oral anticoagulant drugs such as aspirin under the guidance of the doctor to prevent thrombosis. 2. Infection. Spleen belongs to one of the body’s immune organs, some patients with cirrhosis will have obvious immune dysfunction due to splenectomy, which will cause serious infection and even infectious shock. It is recommended that cirrhotic patients decide whether or not to undergo splenectomy under individualized evaluation by a professional physician, and carefully analyze the pros and cons in order to obtain the best prognosis.