The Down’s syndrome test is scary no matter which item shows high risk, but the Down’s syndrome test is only an indication of the risk of the disease, and further tests are needed to make a clear diagnosis. Down’s syndrome, or Down’s syndrome screening, is a test carried out in mid-pregnancy to determine the risk of fetal disease by drawing 2mL of venous blood from a pregnant woman and measuring certain specific markers in the serum, and the main test items include trisomy 21, trisomy 18, and neural tube defects. High risk of trisomy 21: the fetus may have abnormal development of other organs such as face and limbs and abnormal intellectual development. high risk of trisomy 18: the fetus may have abnormal cranial development, congenital heart disease, difficulty in feeding, and low response. High risk of neural tube defects: the fetus may have defects in the central neural tube that do not develop properly. The Down screening is not the final diagnosis. Pregnant women who are at high risk for any of the Down screening tests can have more accurate non-invasive DNA or amniotic fluid or umbilical cord puncture tests. It is important for pregnant women to have a definitive prenatal diagnosis under a doctor’s supervision to determine if there is an abnormality and to decide on subsequent management.