Itchy skin in middle-aged and elderly people is considered to be caused by pruritus, patients need to comply with medical advice for drug treatment, general measures. 1. Etiology: the cause of the disease is more complex, may be due to dry skin, neuropsychiatric, systemic diseases, parasitic infections, drugs and other intrinsic factors, but also may be local stimulation, temperature changes, living environment and other external factors. 2.Treatment: (1) Drug therapy: patients need to use topical glycerine lotion, ethanol preparations containing menthol or camphor to reduce skin irritation, and surface anesthetics such as topical lidocaine cream to relieve itching. It can also be combined with topical antihistamines such as 5% doxepin ointment, or immunosuppressive therapy such as pimecrolimus or tacrolimus. And some patients may also be treated with antihistamines such as oral or intramuscular ipratropium, or selective 5-hydroxytryptamine reuptake inhibitors such as paroxetine and sertraline. Some patients can also be treated with tricyclic antidepressants such as doxepin and amitriptyline, or antiepileptic and anxiolytic drugs such as gabapentin and pregabalin. (2) General measures: patients usually need to pay more attention to their own care, avoid contact with triggers and aggravating factors, stop using the suspected drugs in a timely manner, but also need to avoid scratching, scalding, friction and so on, so as not to aggravate the symptoms. It is recommended that middle-aged and elderly people with symptoms of itchy skin, according to the cause of the doctor’s orders to take targeted treatment.