Clinical research shows that the recurrence rate of colorectal cancer is 30%~40% in 3~5 years after simple surgery, and receiving postoperative adjuvant chemotherapy can reduce the risk of recurrence and metastasis, thus improving the survival rate of patients. However, many patients give up adjuvant chemotherapy or have difficulty in adhering to a full course of adjuvant chemotherapy due to the fear of toxic side effects of chemotherapy. In fact, the doctor’s recommendation is essential, patients should not lose out on small things, affecting the prognosis. “It is not desirable to give up effective adjuvant chemotherapy after surgery. Some patients think that there is no need to receive other treatments because the cancer has been removed by surgery; some patients think that they can do without chemotherapy due to the fear of toxic side effects of chemotherapy. In fact, surgery is only a local treatment, while chemotherapy is the real systemic treatment. Malignant tumor like colorectal cancer is often a systemic disease, which may have local or distant metastasis. Especially for patients with stage II or III, even if radical surgery is performed, it often becomes a trigger for postoperative recurrence and metastasis due to the presence of tiny metastatic foci that are still undetectable at the time of surgery. Adjuvant chemotherapy happens to be an effective means of treating such foci, which can well control or even eliminate the foci that are difficult to detect after surgery, and reduce the risk of distant metastasis and recurrence. Adjuvant chemotherapy should be used as early as possible as long as the functions of organs basically return to normal after surgery and the chemotherapist recommends chemotherapy according to the condition of the patient, colorectal cancer patients should be treated with adjuvant chemotherapy as early as possible and insist on completing the course of treatment. It is undesirable to give up the adjuvant chemotherapy or fail to do the full course of treatment because of the fear of toxic side effects of chemotherapy. This year, with the advancement of medical standards, chemotherapy drugs and chemotherapy modalities have made great progress. Postoperative adjuvant therapy for patients can choose oral chemotherapy with precise efficacy and low toxicity and side effects, such as Heroderma. Choosing appropriate chemotherapeutic drugs can not only eliminate patients’ fear of toxic side effects of chemotherapy, but also help patients to adhere to adjuvant chemotherapy, further control the disease and reduce the risk of metastasis and recurrence of colorectal cancer.