Patients with cirrhosis usually present with hypersplenism and symptoms of portal hypertension. Resection of the spleen not only relieves hypersplenism, but also reduces portal pressure. After splenectomy, there will be some complications, the common ones are venous thrombosis, lung infection, intra-abdominal hemorrhage, intra-abdominal infection and pancreatic fistula. 1. Venous thrombosis: Splenectomy can lead to a rise in the number of platelets in the patient’s body, coupled with changes in the hemodynamics of the portal venous system after splenectomy, further promoting the formation of venous thrombosis. 2. Lung infection: the spleen is one of the body’s immune organs, and its removal can affect the body’s immune function, making patients more susceptible to bacterial infections. In addition, the use of ventilator during surgery and the accumulation of sputum in the respiratory tract are also likely to lead to lung infection. 3. Intra-abdominal hemorrhage: After splenectomy, bleeding may occur due to poor or loose vascular ligation or patient’s coagulation dysfunction. Patients show signs of circulatory disorders such as decreased blood pressure, weakened pulse and pallor. 4. Intra-abdominal infection: Inadequate drainage, inflammation or necrotic tissue retention during surgery can lead to intra-abdominal infection. 5. Pancreatic fistula: during splenectomy, physicians need to treat the patient’s splenic door, and during the process of treatment, part of the pancreatic tissue will be removed, resulting in the exposure of the pancreatic duct, and if the ligature suture is not secure or slipped, it can lead to pancreatic fistula. For patients with cirrhosis who experience complications or other discomforts after splenectomy, they should immediately go to the relevant departments of regular hospitals to avoid delays and adverse consequences.