Transaminase 500+ is not necessarily life-threatening, and needs to be judged according to the specific condition. For example, drug-related liver damage is usually not life-threatening; for example, upper gastrointestinal hemorrhage in the decompensated stage of cirrhosis, it may be life-threatening. Transaminase 500 is more likely to be considered in the presence of drug-related liver damage, viral hepatitis, cirrhosis, hepatocellular carcinoma and other diseases. 1. Pharmacological liver damage: Generally it is the abnormal liver function affected by drugs, and the transaminases can be normalized after stopping or changing drugs. It has little effect on the quality of life and survival. 2. Cirrhosis decompensated stage: there may be complications such as hepatic encephalopathy, ascites, upper gastrointestinal bleeding, hepatorenal syndrome and so on, which have certain influence on the quality of life and survival. Especially upper gastrointestinal bleeding can be life-threatening if not effectively controlled. Whether transaminase 500 is life-threatening or not, it is recommended to consult a doctor to analyze the situation.