The causes of enlarged mesenteric lymph nodes include inflammation, malignant tumors, etc. It is necessary to clarify the cause of the disease and then actively treat the cause. 1. Inflammation: It is mostly seen in children’s respiratory tract infection, or gastrointestinal tract inflammation stimulation will cause mesenteric lymph node enlargement. It is recommended that anti-infective treatment be given as prescribed by the doctor to address the cause of the disease. If the condition is mild children’s respiratory tract infection, can take azithromycin, cefaclor treatment; for gastrointestinal tract inflammation, can take levofloxacin, amoxicillin, cefaclor and other antibiotic treatment; serious infections, can be used intravenously ceftriaxone sodium and other antibiotic treatment. 2. Malignant tumors: bladder cancer, intestinal cancer, stomach cancer, liver cancer and other malignant tumors will cause lymph node enlargement after the tumor cells spread to mesenteric lymph nodes. Surgery can be performed to remove the primary tumor and clear the mesenteric lymph nodes, after which radiotherapy (e.g. 5-FU, mitomycin, etc.) and targeted therapy can be given to inhibit the growth of the tumor, reduce the tumor foci and improve the prognosis of the disease. Therefore, it is recommended to go to the hospital in time to receive examination to clarify the cause of mesenteric lymph node enlargement, and actively cooperate with doctors to receive standardized treatment.