SLE is common in women of childbearing age and is less common in men, but many men can be seen with SLE. If a male patient develops fever, hair loss, mouth ulcers, joint swelling and pain, as well as wheezing and chest tightness after activity, he needs to be further screened for SLE, and it is recommended to further check the inflammation index, blood sedimentation and C-reactive protein, and to check the blood routine. At the same time, autoantibody examination should be conducted, common antibody examination includes anti-nuclear antibody and anti-ENA antibody, and complement and 24-hour urine protein quantification should be checked, through the above examination can determine whether there is SLE.