Estradiol tablets for women have side effects. Estradiol tablets are mainly used to supplement estrogen in women’s body, the main side effects are: 1) water and sodium retention in the body, long-term use can cause edema and even obesity. 2) changes in the endometrium, long-term use of estradiol may cause cancer of the endometrium or cancer of the cervix. 3) triggers blood clots, women with a history of smoking and postmenopausal women in the application of estradiol can cause increased blood viscosity, increasing the risk of blood clots. 4) taking estradiol may aggravate existing diseases such as uterine fibroids, endometriosis. The use of estradiol may increase the viscosity of the blood and increase the risk of blood clots. 4. The use of estradiol may aggravate existing diseases, such as fibroids and endometriosis, which are directly related to estrogen levels.