Platelets as high as 608 x 10⁹/L, in case of primary thrombocythemia, can be treated by giving medicines such as blood cell separator to remove platelets, hydroxyurea, dipyridamole etc. In case of secondary thrombocytosis, the primary disease needs to be treated, and blood cell separator can also be given to remove excessive platelets, oral aspirin to prevent thrombosis, and so on. Thrombocytosis is diagnosed when the platelet count is ≥400×10⁹/L, regardless of clinical symptoms. The treatment of platelets as high as 608×10⁹/L can be categorized into two types: primary and secondary. 1. Primary: It can be seen in primary thrombocythemia, true erythrocytosis, chronic granulocytic leukemia, etc. Hydroxyurea, cyclophosphamide, azidothymidine phenylbutyrate, melphalan and other myelosuppressive drugs can be given, and platelet isolation can also be given to reduce the number of platelets to improve the symptoms, and interferon can inhibit the production of megakaryocytes and shorten the period of platelet survival. Dipyridamole, aspirin, and indomethacin prevent platelet aggregation. Refractory thrombocythemia can try anagrelide. 2. Secondary: asymptomatic does not require special treatment, treatment of the primary disease can be, such as infection caused by the need to be given levofloxacin and other anti-infective treatment. Symptoms or thrombus, should be given treatment, if necessary, can be given to blood cell separation technology to remove excessive platelets, oral aspirin and other anti-platelet aggregation drugs to prevent thrombosis. Platelets as high as 608 × 10⁹ / L after the diagnosis of thrombocythemia, it is recommended that early standardized treatment under the guidance of a physician, in order to reduce the adverse effects of the disease. The above drugs need to be used under medical supervision.