For 46-year-old women, if there is a pituitary tumor will affect the function of the pituitary gland in the gonadal axis of the human body, which in turn affects the body’s ovarian secretion of estrogen and progesterone, so there will be the clinical manifestation of the menstrual period has not been clean, so should follow the doctor’s instructions through medication, surgery, radiotherapy and other ways to actively treat the primary disease. 1. Drug treatment: (1) Bromocriptine: this drug is a dopamine agonist, which competitively binds with dopamine receptors to reduce prolactin level and shrink the tumor, but it requires long-term treatment and may cause nausea, vomiting, headache and other discomforts when taking the drug. (2) Octreotide: This drug is a growth inhibitor analog, which can specifically inhibit growth hormone, thus improving acromegaly caused by pituitary tumor. 2. Surgical treatment: Currently, localized lesions can be removed by transnasal butterfly microsurgery or craniotomy. Among them, microadenomas and most macroadenomas are treated by transsphenoidal microsurgery; if the tumor has already invaded the suprasaddle or parasphenoidal tissues, craniotomy is usually chosen. 3. Radiotherapy: Radiotherapy is generally used as an adjunctive treatment to medication or surgical treatment, destroying the function of the tumor through rays, thus reducing the risk of incomplete removal of the lesion by surgery and possible recurrence after surgery. For 46-year-old women with pituitary tumors whose menstrual periods have not been clean, it is recommended that they go to the gynecology department of a regular hospital, and choose the appropriate way of active treatment under the guidance of the doctor in order to obtain the best therapeutic effect.