Obsessive-compulsive disorder taking sertraline can be vaccinated if the condition is stable without obvious physical discomfort and there are no contraindications to the vaccine components, but it needs to be judged in conjunction with the patient’s condition. At present, the new crown vaccine is mainly inactivated vaccine, most people have not been reported serious adverse reactions after vaccination. Sertraline for OCD can be administered if there is no special discomfort and the patient’s condition is under stable control. If the patient’s condition is still unstable, in the progressive stage of OCD or not under effective control, it is recommended to postpone vaccination. During the treatment of obsessive-compulsive disorder patients, it is recommended to go to the relevant departments of regular hospitals or the CDC consultation, clear condition to decide whether the vaccination, do not blindly vaccination lead to serious adverse consequences.