Whether diabetic nephropathy stage III is serious or not mainly depends on the severity of the condition and its treatment effect, and cannot be generalized. Diabetic nephropathy is the damage to the kidneys after diabetes has developed to a certain stage. If the condition is mild, the progression of kidney disease can be slowed down through effective treatments such as active control of hypertension, hyperglycemia and reduction of proteinuria, which is usually not serious at this time. If the condition is more serious and the treatment is not effective, it may develop into uremia as the condition progresses. It is relatively serious at this time. Patients with diabetic nephropathy are advised to go to regular hospitals in time and standardize the treatment under the guidance of doctors.