The causes of pain in the ball of the foot may include physiological and pathological, the latter may include metatarsal tendon membrane strain, trauma, neuropathic pain, orthopedic diseases such as lumbar intervertebral disc herniation and so on. 1. Physiological reasons: If the feet are cold, the foot capillaries can not circulate normally, the metabolism of toxins will slow down, and may cause pain in the ball of the foot for a long time. There is also usually walking too long, due to the pressure of the center of the foot and the pain. 2. Pathologic causes: (1) Metatarsal tendon membrane strain: usually due to long time walking or excessive weight bearing. Note that it does not need special treatment and will get better after proper rest. (2) Trauma: it may also be caused by trauma, and active treatment is needed to relieve the symptoms. (3) Neuropathic pain: if this is the case, there can be obvious characteristics such as pinprick pain, can feel particularly painful. Usually, it cannot be cured by itself, and should be treated in hospital in time. (4) Orthopedic diseases: If you suffer from orthopedic diseases such as lumbar disc herniation, it can lead to compression of distal nerves, which will cause symptoms of fever or pain in the soles of the feet. When such symptoms appear for a long time without relief, it is recommended to go to the hospital in time to clarify the cause of the disease and then treat it.