Non-steroidal anti-inflammatory drugs are represented by aspirin, in addition to anti-inflammatory and analgesic drugs such as ibuprofen and Intacrine, which can produce irritation to the gastric mucosa. The normal gastric mucosa contains cyclooxygenase, also known as COX-1, which promotes the secretion of prostaglandins from the gastric mucosa. It causes gastric lesions because the balance between factors that attack the gastric mucosa and factors that protect the gastric mucosa is broken, for example, if the attacking factors are strengthened and the defending factors are weakened, then gastric mucosa lesions can be caused. The prostaglandin is the protective factor of gastric mucosa, and NSAIDs mainly lead to the reduction of prostaglandin secretion in gastric mucosa, which in turn weakens the protective effect of gastric mucosa and causes lesions such as inflammation of gastric mucosa.