The causes of occasional throbbing of the lips and corners of the eyes include physiologic and pathologic factors, and the pathologic factors include facial nerve paralysis, facial muscle spasm and so on. 1. Physiological factors: long-term mental stress, staying up late and not getting enough sleep, anxiety and depression, excessive tension, etc. can cause the symptoms of occasional throbbing of the lips and corners of the eyes of the patients, the patients can effectively relieve the symptoms by actively exercising, developing good habits of work and rest, and maintaining a healthy state of mind. 2. Pathological factors: patients with facial nerve palsy can be manifested as crooked corners of the mouth, speech leakage and other uncomfortable symptoms, patients can follow the doctor’s instructions to use methylcobalamin and other drugs to improve the uncomfortable symptoms. Facial muscle spasm patients do not have other positive signs of neurological damage, but can also appear in the corner of the eye jumping, twitching and other discomfort symptoms, the cause is not clear. It is recommended that patients with significant lip and corner of the eye twitching should seek prompt medical attention to assess their condition and follow the doctor’s instructions for treatment.