Tooth nerve pain requires dental treatment or trigeminal nerve closure. The common cause of dental neuralgia is inflammation of the dental nerve, symptoms of pulpitis, painful eating, or severe nighttime pain, which affects normal work or life and requires dental treatment. If the apical foramen of the tooth has been formed, root canal treatment can be performed to remove the infected nerve, followed by root canal disinfection and tight filling after the inflammation has completely subsided. In case of a large defect, crown protection can be performed. In the case of young permanent teeth with unformed apical foramina, the nerve of the root needs to be preserved and the tooth then undergoes apical induction. Dental neuralgia is sometimes associated with trigeminal neuralgia. A lesion in a branch innervated by the trigeminal nerve can cause severe pain that is similar to dental nerve pain, with a unique trigger point, such as a particular piece of skin, that induces pain when touched. This condition can be treated with closure of the trigeminal nerve to relieve the pain. Or it can be treated with medication, such as carbamazepine. Therefore, dental nerve pain requires root canal treatment of the tooth or medication of the trigeminal nerve as well as closure.