Patients with recurrent anal fissures with painful bowel movements, bleeding bowel movements, and non-healing can use erythromycin ointment or Ma Yinglong hemorrhoid cream, or mupirocin ointment to apply topically to the fissure. At the same time, it can be combined with the use of anal pessary, Ma Yinglong hemorrhoid suppositories, or Puji hemorrhoid suppositories nano-anal to play a role in promoting wound healing. However, if the conservative treatment does not achieve significant results, in such cases, the clinic should consider the possibility of recurrent attacks and the formation of old anal fissures, which require surgical treatment methods. The common surgical method for anal fissure is to cut out the internal anal sphincter, which can completely solve the situation of repeated non-healing caused by anal fissure.