Nosebleed in children is called epistaxis in Chinese medicine, and epistaxis in children in the middle of the night may be related to exuberant liver fire, exuberant gastric fire, and insufficiency of qi and blood, so the cause of epistaxis in children should be found out by medical practitioners in a timely manner, and then treated according to the cause, and medicines such as Longdian Diarrhea Liver Pill, Jade Maiden Decoction and Gui Spleen Pill can be taken respectively. 1. Exuberant liver fire: Exuberant liver fire will lead to epistaxis in the middle of the night, accompanied by red, swollen and painful eyes, dizziness and headache, etc. Gentian diarrhea and liver pills can be taken, which have the efficacy of clearing the liver and gallbladder and facilitating the effect of dampness and heat, and it is important to note that children must be taken under adult supervision, and pregnant women should be cautious in taking these pills. 2. Excessive fire in the stomach: Excessive fire in the stomach leads to epistaxis in the middle of the night, accompanied by constipation, bad breath, irritability and thirst, etc., and can take Jade Maiden Decoction, which has the efficacy of clearing heat in the stomach and nourishing yin in the kidneys, but pay attention to the loose stools, and those with deficiency of yang in the spleen and stomach are advised to take it with caution. 3. Qi and blood insufficiency: children may suffer from epistaxis in the middle of the night, accompanied by symptoms such as panic, shortness of breath and fatigue, etc. They can take Spleen Pills, which can benefit qi, strengthen the spleen and nourish blood to calm down the spirit, but it is not suitable for those who suffer from colds and fever, and children need to be supervised by an adult to take the medicine. Treatment needs to follow the doctor’s instructions, under the guidance of the doctor to identify the evidence of the use of drugs.