Children’s fever with hot hands and cold feet may be related to the imperfect development of the child’s nervous system. Children’s central nervous system development is not yet mature, easy to vasodilatation confusion, may lead to children fever hands hot and feet cold performance. Generally speaking, children’s fever with hot hands and cold feet suggests that the body temperature is in the rising period, because the blood circulation in the feet is relatively poor. At this time, parents can use their hands to rub the child’s feet hot, or use warm water to soak the feet, to promote blood circulation in the feet. However, if the child’s skin color and face are not normal, it is necessary to go to the regular hospital in time to receive treatment. Parents must pay attention to the monitoring of body temperature when the child has a fever, and give the child more water to promote sweating, which plays a cooling effect. There may be other reasons for children’s fever with hot hands and cold feet, so it is recommended that parents can take their children to the hospital for early detection of the problem.