Eczema is an inflammatory skin reaction caused by a variety of internal and external factors that cause intense itching. There are three phases: acute, subacute, and chronic. The acute phase has a tendency to exude, while the chronic phase is infiltrative and hypertrophic. Some patients directly present with chronic eczema. The lesions are polymorphic, symmetrical, pruritic, and prone to recurrence. Most of the current treatments for eczema are symptomatic and provide temporary relief, but are prone to recurrence and have a significant impact on quality of life. The treatment of intractable eczema requires comprehensive and systematic treatment. If conventional treatment is not effective, the following methods can be referred to: 1. Hydroxychloroquine: Hydroxychloroquine, 1 capsule orally twice daily. But need to monitor blood routine, liver function and eye fundus; 2. Response stop: 25mg-50mg bid orally, better efficacy for hypertrophic chronic plaque. But need to pay attention to side effects such as causing peripheral neuritis, thrombosis, constipation, etc.; 3. Reglan polysaccharide tablets: 10mg tid orally. It is necessary to pay attention to reproductive inhibition, as well as the effect on blood picture, and the effect on liver function; 4.Chinese medicine, according to the evidence can choose the corresponding Chinese patent medicine or Chinese medicine soup. 5. Examine the causative factors and treat the symptoms.