The difference between rabies vaccine and immune globulin is the drug reaction and the time it takes to work. 1. Drug reaction: The rabies vaccine is injected into the human body to produce antibodies to resist the rabies virus and prevent rabies attacks. Immunoglobulin can be directly combined with rabies virus through injection to achieve the effect of preventing rabies, the two drug reaction is different. 2. The time of functioning is different: after rabies vaccination, it takes about 15 to 20 days to produce antibodies to the rabies virus. Due to the longer time to produce antibodies. After the injection of immunoglobulin, it can quickly combine with the rabies virus in the body, and the injection of immunoglobulin within 24 hours can effectively prevent the rabies virus. The rabies vaccine is a part of the rabies virus, which is injected into the body as an antigen so that the body’s immune system recognizes it and produces antibodies accordingly to gain immunity against the rabies virus. And immunoglobulin provides immediate immunity against rabies. The immunity produced by the rabies vaccine is called active immunity, and the immunity acquired by immunoglobulin is called passive immunity.