Gastrointestinal bleeding is a very common disease in clinical practice. Gastrointestinal bleeding can be very dangerous to the health of patients, so timely diagnosis and treatment are necessary. During the treatment process, the patient usually needs bed rest. Nursing patients need to record the patient’s blood pressure, pulse, and bleeding volume at all times, and keep the patient’s airway open to avoid choking in case of vomiting blood. If the patient has a large amount of bleeding, food intake should be reduced, if the bleeding is relatively small, food can be appropriate. When the patient’s hemoglobin is lower than the standard amount, enough whole blood should be injected immediately, and also to prevent the appearance of acute pulmonary edema caused by too much blood transfusion. The treatment of upper gastrointestinal bleeding disease is very critical and must be timely. Early diagnosis and early treatment are essential, especially for determining the site and cause of bleeding. If the bleeding is vomiting blood or black stool, the site of bleeding is most likely the stomach or esophagus. If it is simply black stool, the site of bleeding should be in the duodenum. Understanding common sense has different ways of caring for patients with bleeding in different parts of the body, which can also have a good effect on the relief of the disease.