Diffuse enlargement of the thyroid gland may be caused by iodine deficiency, abnormal thyroid function, thyroiditis, etc. Treatment should be determined according to the cause and the degree of enlargement. The main methods of treatment include regular observation, lifestyle improvement, medication and surgery. 1. Regular observation: If the diffuse goiter is accompanied by normal thyroid function and there are no obvious symptoms of compression, treatment is usually not needed, and regular observation is all that is needed. 2. Lifestyle: If simple goiter is related to iodine deficiency, attention should be paid to timely improvement with iodized salt, kelp and other iodine-rich foods. In addition to iodine supplementation, it is also necessary to carry out appropriate physical exercise, maintain an optimistic state of mind, regular work and rest, and combine work and rest. 3. Drugs: If it is caused by thyroiditis, you can consider the use of glucocorticoids or antibiotics and other drugs for symptomatic treatment. If it is caused by Graves’ disease, you can apply anti-thyroid drugs, such as methimazole or propylthiouracil. If accompanied by hypothyroidism, oral levothyroxine sodium tablets are usually needed for hormone replacement therapy. 4. Surgery: If the thyroid enlargement is more serious and there are obvious compression symptoms, surgery can be chosen. Diffuse enlargement of the thyroid gland requires prompt medical attention to clarify the cause of the disease and treat the symptoms.