Low blood amylase may be related to physiological metabolism and pathological diseases such as salivary gland atrophy, renal failure and other factors. Physiological low blood amylase is mostly related to body metabolism, when the body loses more water and replenishes less, it can lead to the decrease of salivary secretion, which is manifested as low blood amylase. At this time should be timely supplemental water, close dynamic observation can be. Pathological diseases such as salivary gland atrophy can lead to gland atrophy, amylase secretion is reduced, resulting in low blood amylase. Artificial saliva can be used to relieve symptoms. If the atrophy is severe and accompanied by sclerosis, surgical removal can be used to prevent malignant changes to improve symptoms. In renal failure, the glomerular reabsorption rate decreases, resulting in an increase in blood amylase excretion, which leads to low amylase in the serum. At this time, we need to give treatments to protect the kidney for the primary disease, and if necessary, dialysis or kidney transplantation is feasible. If you find that the blood amylase is low, you should consult a doctor in a timely manner, under the guidance of the doctor’s treatment, do not take medication without authorization, in order to avoid delaying the condition. Pay attention to rest on weekdays, quit smoking and drinking, and keep a regular routine.