Many women look to IVF technology for infertility treatment, yet cruelly, from clinical data, the success rate of IVF for women over 45 years of age is low, or the probability of miscarriage after pregnancy is also elevated. Why are older women prone to failure when they undergo IVF? Failure of IVF in older women: Poor quality of eggs or sperm, resulting in poor quality of the embryo itself is the main cause. The best age for a woman to have a baby is 25-29 years old. The success rate of IVF is higher at this stage. Women over 35 years old are senior women, their fertility plummets and the number of available eggs in the ovaries decreases significantly. Therefore, when promoting ovulation, doctors will increase the dosage of drugs, but the ovaries of senior women will respond poorly to the ovulation drugs, or there will be no growth of follicles after the drugs and they will be terminated halfway; even if some patients’ ovaries still respond well, but the overall number of follicles is low and the quality is poor, there may be abnormal fertilization, poor embryo development and no good embryos for transfer. A few good embryos may be harvested in some patients, but the endometrium becomes less tolerant in older women, and the success rate after later embryo transfer decreases or the rate of miscarriage after pregnancy increases. Therefore, IVF success rate decreases rapidly with increasing age. It is an unchangeable fact that women’s ovarian function will decline and egg quality will get worse due to advanced age. Environmental pollution, heavy life and work stress, unhealthy lifestyle habits, etc., add to the ovarian function of older women, making it more difficult for them to have children. Women with heavy psychological stress will have their endocrine secretion affected and their blood vessels will be in a state of constriction for a long time, which affects the local blood flow to the uterus and ovaries, and the tension in the nervous system will cause abnormalities in the release of some neuromediators, resulting in disorders in the contraction of the muscles of the uterus and fallopian tubes, causing embryos to fail to implant and resulting in treatment failure. Therefore, it is very important to relieve psychological stress, to communicate between the doctor and the patient, and to have mutual understanding and encouragement between the couple. Therefore, too much stress before and after the transfer in advanced women can also lead to transfer failure. Thus, it seems that IVF failure is quite common in advanced age women, so it is important to be well prepared psychologically and physically before IVF, and to cooperate with the doctor for active treatment and joint efforts to welcome a good pregnancy.