In the treatment of diabetes, it is very important to lower the sugar in a gradual and safe manner. In some cases, we should not rush to achieve “normal value”, but to capture the “nun”, slowly. For middle-aged and old-aged diabetic patients, the organ function decreases and the body’s response ability is poor, not only the ability to lower blood sugar is reduced, but also the ability to raise blood sugar after the blood sugar drops is reduced. This means that the ability to “regulate blood sugar” is reduced, and the so-called “regulation” is a two-way ability. Thus, in the case of combined cardiovascular and cerebrovascular diseases, arteriosclerosis, vascular plaque, tissue infarction, etc., the supply of nutrition and oxygen to the heart, brain and other important organs is insufficient, and if hypoglycemia is not corrected in time, it will cause immeasurable and significant damage. The elderly are unresponsive, and this is reflected in many diseases, such as: in the case of infection, elderly patients may have delayed fever or fever is not high, white blood cell elevation may not be obvious; such as hyperthyroidism, elderly patients may not be excited, easily agitated, etc., but show indifference; anemia, the elderly have not complained of obvious weakness and easy fatigue …… many manifestations. There is only one reason for this, and that is the decreased responsiveness of the body! Therefore, in non-acute surgery and other urgent need to immediately control blood sugar, blood sugar control to gradual is appropriate. As a principle, “gradual and orderly” is an important principle to be observed in most cases. For example, if you have long-term anemia, a sudden transfusion of too much blood may lead to heart failure; if you have a long-term salt-poor diet, a sudden salt supplementation too fast may lead to nerve damage. Therefore, what we generally call “normal” is not a goal that needs to be reached immediately. Clinically, we can see some patients who do not pay attention to the disease, their blood glucose can be above 20mmol/L for a long time, without obvious conscious symptoms. This phenomenon is also common in other disciplines, and we often say “adapted”. Since we have “adapted” to this state, we suddenly make it reach “normal value”, which is bound to cause discomfort. In the course of diabetes, the damage of hyperglycemia is chronic, and usually the complications appear after 5 years of persistent hyperglycemia, but the damage of hypoglycemia is immediate, and even death at once! Moreover, if the medication is overdosed, the occurrence of hypoglycemia can cause several days of blood glucose disorder and bring trouble to the follow-up work. Whether it is oral medication or insulin, apply a slightly smaller dose than estimated to reach the “normal value”, “indulge”, and then gradually increase the dose under the monitoring of blood sugar, in order to achieve the ideal state, and this process is only a few days. Usually when we talk about a drug, we will say “safe and effective”, safety is always in the front, safety is the escort for effective.