Contraindications are relative and not absolute, with the exception of endometrial cancer. The medical practice in China is to exclude tumors, which can be used normally in the absence of tumors, and in the presence of tumors, which should be decided according to the type of tumor. Tumors are divided into hormone-dependent tumors and non-hormone-dependent tumors. In the case of hormone-dependent tumors, such as endometrial cancer, breast cancer, and certain ovarian cancers, use is not recommended. Non-hormone-dependent tumors may be considered appropriately, such as parathyroid cancer. However, endometrial cancer, breast cancer, and certain ovarian cancers are not absolute contraindications per se. Another principle in treatment is to conform to national characteristics and conditions. Therefore, for Chinese people, if there is cancer, it is no longer used, which has a lot to do with the Chinese medical market and the poor mutual trust between doctors and patients. For example, after cervical cancer surgery, after radiotherapy and chemotherapy, vaginal atrophy or urinary system damage, patients are very painful, so they can use some locally, because some local drugs do not pass through the blood. Estrogen receptor negative for breast cancer can also be used under close observation, so there is no absolute contraindication. Treatment should be individualized through the different needs of the patient. If a breast cancer patient has particularly severe age-related vaginitis itself, vaginal administration may be an option. In terms of indications, there is a window period, and application for patients within five years of menopause will have a protective effect on the heart and cardiovascular. Due to the lack of publicity, patients in China have a general fear of cancer. In fact, there are many people who can survive with tumors for life, and it is important to enhance scientific education. The clinical use of sex hormones has great flexibility and is not limited, but varies according to individual patient differences, and it is related to the experience accumulated by clinicians in their work. Doctors need to give some guidance to patients to make them fully trust and adjust the dosage appropriately according to the changes in their conditions, which are all very important.