A urine sugar of 4 plus is usually indicated clinically by urine sugar (++++). There are many reasons for these conditions, not necessarily suffering from kidney disease, but also may be related to endocrine diseases, such as diabetes mellitus. If there are 4 plus urine sugar, patients should promptly go to the hospital to rule out the presence of diet, drugs and other causes of increased urine sugar; also need to carry out blood glucose testing, glucose tolerance test, fasting as well as two hours after meals blood glucose and other tests to see if the patient has diabetes; in addition, you can also carry out urine routine, kidney function testing, etc., to determine the cause of the disease, to facilitate the later take targeted treatment. 1, endocrine diseases. Urine sugar 4 plus, clinically common in diabetes, patients with a relative or absolute reduction in insulin secretion, or the emergence of insulin resistance, affecting the level of blood glucose and urine sugar in the body, appearing elevated urine sugar, after treatment urine sugar value can be gradually reduced. There is also a special category of diabetic population, namely gestational diabetes patients, these patients in general after the birth of urine sugar will gradually reduce on their own, a few people still need to be treated, but all need regular follow-up to observe changes in urine sugar; 2, kidney disease: such as renal diabetes, due to reduced renal tubular reabsorption function, and diabetes. Patients with diabetic nephropathy are also prone to the above-mentioned conditions, which are among the complications of diabetes. In addition, if the patient has previous brain diseases or neurological diseases, such as skull fracture, encephalitis, epilepsy, etc., which affect the patient’s nerves as well as endocrine, it may lead to the breakdown of liver glycogen and elevated blood sugar, which in turn may lead to elevated urine sugar, which will also gradually recover after removing the effects of the original disease. If patients use certain drugs for a long time, they may also have urine sugar 4 plus test results, common ones are hormonal drugs, caffeine, propylamines, salicylates, etc. After stopping the drugs, urine sugar can be gradually restored. Some Chinese herbs can also affect urine sugar test results, such as rhubarb, yellow lily, scutellaria, etc. Therefore, it is recommended that patients actively inform their doctors of their medication and other manifestations after the appearance of urine sugar for further diagnosis.