The thickening and bulging of the flesh under the nails is usually caused by gray nails, onychomycosis, trauma, calcium deficiency and other factors, which require anti-infection and calcium supplementation. 1. Gray nails can cause thickening of the flesh underneath, which is generally referred to as onychomycosis in clinical practice, caused by dermatophytes invading the nail plate, leading to turbidity, thickening and shedding of the nail plate and other symptoms, with the development of the disease can also lead to thickening of the flesh underneath the nails, which is currently treated with drugs such as itraconazole capsules, terbinafine hydrochloride tablets and other medications, and in severe cases, surgical treatment is required. 2. nail groin infection can also cause thickening of the meat under the nails, nail groin infection is mainly caused by microbial infection of the tissue around the nails, making the local redness, swelling, etc., will also cause thickening of the meat under the nails, more mupirocin ointment, fusidic acid cream and other medications, when serious local abscess formation requires abscess drainage. 3. Fingernail by the external force of extrusion or injury, and then recover from the formation of granulation tissue to scar tissue, will also make the flesh under the nails raised and thickened, may also be accompanied by local pain, swelling and other symptoms, usually serious words need to undergo surgical treatment. 4. Because of eating too little calcium-containing food, leading to a lack of calcium in the body, uneven nails also make the flesh under the nails protruding, serious cases can also be accompanied by muscle spasms, developmental delays, etc., at present the use of calcium gluconate tablets for treatment. It should be noted that the use of the above drugs should be under the guidance of a physician.