Liver and spleen enlargement, that is, the size of the liver and spleen exceeds the normal range, usually due to infectious and non-infectious factors. 1. Infectious factors: including viral, bacterial, fungal and parasitic infections. For example, viral hepatitis can cause liver and spleen enlargement as well as gastrointestinal symptoms, mostly accompanied by jaundice. Bacterial liver abscess can also cause enlarged liver and spleen, accompanied by fever, nausea and other uncomfortable symptoms. For people with low immunity, cryptococcosis, trichinellosis and other fungal infections can also occur, resulting in a large liver and spleen. 2. Non-infectious factors: such as portal hypertension, congestive heart failure, Buga syndrome, cirrhosis, hematologic diseases, rheumatoid immune diseases, tumors and other diseases, can also cause hepatosplenomegaly, abdominal varicose veins, upper gastrointestinal bleeding. Alcohol, carbon tetrachloride and other chemicals can also cause liver cell damage, toxic hepatitis, resulting in hepatosplenomegaly. Some blood system diseases and malignant tumors metastasized to the liver can also lead to hepatosplenomegaly. There are many causes of hepatosplenomegaly, and the specific cause requires a visit to the hospital for further diagnosis and treatment.