The need to reduce γ-glutamyltransferase is usually γ-glutamyltransferase is high in the population, and its elevation can be seen in physiological factors, but also seen in fatty liver, pancreatitis and other diseases, the former can be adjusted to adjust the lifestyle, the latter caused by the doctor’s guidance can be targeted treatment, such as fenofibrate, metformin, omeprazole and other medication, surgical treatment, and so on. 1. Physiological factors: a lot of late night, fatigue may cause liver function abnormality, resulting in γ-glutamyl transferase elevation, such cases should maintain a good work and rest, appropriate rest, avoid drinking alcohol. 2. Disease factors: fatty liver should quit drinking, avoid eating high-fat food, appropriate exercise, with dyslipidemia can use fenofibrate and other lipid-lowering drugs treatment, with elevated blood sugar can use metformin to lower sugar. Pancreatitis acute attack need to fast, correct the water and electrolyte disorders, can be treated with acid-suppressing drugs such as omeprazole, can also consider endoscopic or surgical treatment. After excluding physiological factors, it is recommended to go to the hospital and follow the doctor’s instructions for treatment.