To prevent progesterone suppositories from discharging, you can put toilet paper in your underwear. Progesterone suppositories are mainly used to treat menstrual disorders caused by insufficient secretion of progesterone, preeclampsia and other diseases. The drug is usually given vaginally, and after the drug is absorbed, the residue will be mixed with the vaginal secretions and run out of the body, polluting the underwear. In this case, you can put toilet paper inside your underwear in order to keep them clean, and it will not affect the therapeutic effect of progesterone suppositories. However, the use of toilet paper should be clean and preferably sterilized by high temperature to avoid vaginal inflammation. The medication should be used under the supervision of a clinician to avoid adverse drug reactions.