The common specification of spironolactone tablets is 20mg, 1~2 tablets at a time, the dosage should be adjusted according to the disease to be treated, and renal function should be monitored when used in elderly patients. Because spironolactone is mainly excreted by the kidneys, when the patient’s kidney function is impaired, the risk of adverse reactions is greater, the elderly are prone to decline in renal function, the use of renal function should be monitored, if the use of liver and kidney insufficiency, should be strictly in accordance with the instructions of the drug under the guidance of the doctor to adjust the dosage or change to other drugs. In general, the regular dose is used. Regular dosage, general adult use, the treatment of edema disease, 40 ~ 120mg per day, 2 ~ 4 times can be taken; the treatment of hypertension, the beginning of 40 ~ 80mg per day, and then adjusted; the treatment of primary aldosteronism, pre-surgery, 100 ~ 400mg per day, the diagnosis of primary aldosteronism, 400mg per day. For the diagnosis of primary aldosteronism, because the elderly are sensitive to this drug, the dosage should be small under the guidance of the doctor. Attention should be paid to the individualization of the drug, the drug has a slower onset of action and a longer maintenance time, the common adverse reactions are hyperkalemia and gastrointestinal reactions, hyperkalemia patients are prohibited. Elderly people are more prone to hyperkalemia and diuretic overdose. If hyperkalemia occurs during drug administration, the drug should be stopped immediately. Avoid intake of drugs or food with high potassium content during drug administration.