Spinal cavernous disease is a chronic progressive degenerative disease of the spinal cord that, if left untreated, can cause sensory or motor impairment in the patient. In addition, it can cause a variety of diseases and even paralysis, which can be life-threatening. Therefore, it is crucial to understand spinal cavernous disease and treat it promptly. The initial manifestations of spinal cord cavitation Because the cavity most often starts from the base of the posterior cervical horn on one side, the early prominent symptom is segmental dissociative sensory impairment, i.e., loss of pain and temperature sensation while tactile and deep sensation exist. Most cases start with asymmetric unilateral sensory loss. The sensory deficit may be reflected by painless skin ulcers, scarring, edema, Charcot joint, and resorption of the terminal finger (toe) bones. Patients are often seen for painless sensation in the fingers or skin burns. In the clinic, we often encounter patients with painless burns on their hands, which were thought to be cold at the time, and the patients were relieved by sweating and moxibustion. Later, the patient was diagnosed with spinal cord cavity only after the symptoms gradually worsened and muscle atrophy appeared. Therefore, we remind all patients that they must go to the hospital promptly for consultation if they encounter temperature and pain perception disorders. Spastic paralysis of the lower limbs gradually appears after the development of spinal cord cavitation lesions that damage the pyramidal bundle and the external pyramidal bundle, along with positive pyramidal bundle signs in both lower limbs. Late symptoms of spinal cord cavitation Spinal cord cavitation often involves the nucleus of the spinal bundle of the trigeminal nerve and presents with onion skin-like pain and temperature deficits in the face, progressing from the lateral to the nasolabial region; involvement of the nucleus of suspicion causes dysphagia and choking; involvement of the nucleus of the hypoglossal nerve extensors and muscle bundle tremors; involvement of the nucleus of the facial nerve presents with peripheral facial palsy; involvement of the vestibulocerebellar pathway presents with vertigo, nystagmus, and gait stability. There are many causes of spinal cord cavitation, such as skull base depression, subungual herniation of the cerebellum is the main cause of spinal cord cavitation, in addition to spina bifida, scoliosis deformity, and often have a family tendency to develop the disease, so it is believed that the disease is related to genetic factors.