Quadruple take 10 days can not adhere to, it is recommended that timely consultation, under the guidance of the doctor to adjust the drug treatment. Clinical quadruple mainly refers to the bismuth plus proton pump inhibitor plus two antibiotics combination drug program, usually used by the root treatment of H. pylori infection. The quadruple combination treatment program needs to be taken for about 10 to 14 days, and then go to the hospital to review the H. pylori bacteria, to see whether to achieve an effective treatment effect. If you can’t stick to the program after 10 days, it is often because of the discomfort caused by the side effects of the medication that make it difficult to stick to. Often in the process of taking four combined medication, may be due to amoxicillin, clarithromycin and other drugs, out of abdominal pain, abdominal distension, nausea, vomiting, loss of appetite and other symptoms of discomfort. At this time, you should consult the doctor in time, and adjust the medication under the guidance of the doctor. In this case, you can consult the gastroenterology department, after the doctor’s comprehensive assessment to decide whether to continue to take or adjust other drugs. In the process of drug adherence, can not stop or reduce the drug, because this can not achieve the required course of treatment, which will lead to poorer therapeutic effect, and even lead to drug resistance. To summarize, usually in the use of the quadruple program for the eradication of Helicobacter pylori, if there are symptoms that make it impossible to continue taking the medication, it is recommended to consult the gastroenterology department in a timely manner, under the guidance of the doctor to carry out symptomatic treatment.