Foreign body sensation in the lower part of throat may be related to chronic tonsillitis, reflux pharyngitis, hypopharyngeal cancer and other diseases, which need to be treated according to different diseases. 1. Chronic tonsillitis: common symptoms are sore throat, cough, dryness, itchiness and foreign body sensation in the throat. Daily use of compound borax gargle, compound chlorhexidine gargle, etc. to clean the mouth. Try to use transfer factor and placenta globulin to improve immunity, use sensitive antibiotics for antibacterial treatment, combined with streptococcal allergens and vaccines for desensitization treatment. 2. Reflux pharyngitis: gastric contents reflux into the throat, causing redness and swelling of the mucous membrane of the throat, and a foreign body sensation in the lower part of the throat. Mosapride and domperidone can be used to promote gastrointestinal peristalsis, and omeprazole and pantoprazole can inhibit the secretion of gastric acid and reduce the irritation of throat. 3. Hypopharyngeal cancer: when the tumor in hypopharynx gradually increases, patients will feel foreign body sensation. It is recommended to clarify the nature of tumor in time and decide specific treatment plan according to the nature and scope of tumor. It is suggested that patients should go to the hospital in time, have a systematic examination to clarify the cause of the disease, and follow the doctor’s instruction to standardize the medication and treatment.