The acne-like pimples at the vaginal opening are painless and itchy and may be caused by pseudo-warts, condyloma acuminatum, molluscum contagiosum and other diseases. 1. Pseudo warts: its cause is not yet clear, may be vaginitis, poor hygiene habits and other factors. It can occur in the pubic area, a dense distribution of small pimples, can be fluffy, fish seed, often no conscious symptoms, manifested in the vaginal opening of the acne-like pimples do not hurt and itchy. 2. acromegaly: acromegaly is mainly caused by human papilloma virus infection, can be in the labia, vaginal opening, clitoris and other parts of the reddish small particles, soft texture, the tip of the slightly sharp. It can be manifested as acne-like pimples at the vaginal opening without pain or itching. 3. Molluscum contagiosum: Molluscum contagiosum is caused by the molluscum contagiosum virus infection, or it may be triggered by factors such as low immunity and frequent sexual life. It can appear in the genitals of the small pimples, the patient can manifest in the vaginal opening of the acne-like pimples painless and itchy. 4. Other: acne-like pimples at the vaginal opening without pain and itching may also be sebaceous cysts, folliculitis and other diseases. There are many causes of acne at the vaginal opening that are painless and itchy, so it is recommended that patients find out the cause of the problem in a timely manner.