Levofloxacin is effective in treating chronic appendicitis and can be used in patients with milder appendicitis. Chronic appendicitis refers to chronic inflammatory lesions of the appendix, such as fibrous connective tissue hyperplasia of the wall, narrowing or occlusion of the lumen, distortion of the appendix, and adhesion to the surrounding tissues resulting in anaerobic bacillus coli infection. Levofloxacin belongs to the quinolone class of antibiotics, against anaerobic bacteria such as Escherichia coli has a certain effect, so appendicitis patients through the use of levofloxacin, can effectively inhibit inflammation, to a certain extent, to alleviate appendicitis pain. For patients with mild appendicitis symptoms, the application of levofloxacin can achieve a better therapeutic effect. But for chronic appendicitis, acute suppurative appendicitis or perforated appendicitis, try not to choose levofloxacin for anti-infection treatment, should be taken in time under the advice of the doctor to take surgical treatment. Because severe appendicitis is difficult to get effective control by levofloxacin drug, if only rely on the use of levofloxacin treatment, peritonitis, phlebitis may occur, so for the serious condition of the patient is not recommended to apply levofloxacin treatment, or surgical treatment is the main. It is recommended that patients with appendicitis should go to the hospital in time for a formal examination and choose the correct treatment under the guidance of the doctor.