Male chromosome 18 inversion can take three generations of IVF and still have a good success rate. Chromosome inversion is a chromosome abnormality in which a piece of chromosome formed by two breaks of chromosome is rejoined after inverting 180 degrees.Chromosome 18 inversion is also a relatively common chromosome variant. Some men with inverted chromosome 18 have no obvious clinical symptoms and can have normal fertility. However, in some men, inversion of chromosome 18 can lead to a decrease in sperm quality, resulting in an increased risk of fertility disorders such as habitual miscarriage, stillbirths, and infertility. Men with chromosome 18 inversion can undergo embryo chromosome screening through three-generation IVF to obtain healthy embryos for transfer in order to improve the pregnancy rate.