Neonatal congenital hypothyroidism may be related to congenital hypoplasia of the thyroid gland and other factors, in the treatment of the main application of thyroxine replacement therapy, such as levothyroxine sodium tablets and so on. Neonatal congenital hypothyroidism is a common intellectual disease, which has no obvious symptoms in the early stage of its development, and may be characterized by short stature and mental retardation in the later stage. If detected in time in the early stage, it can be treated with drugs such as levothyroxine sodium tablets under the guidance of the doctor and the prognosis will be better. Parents need to go to the hospital for timely examination and treatment when they find hypothyroidism in their newborns to avoid irreversible brain damage, which will affect the intelligence and height of the newborns in the later stage.