The causes of stomach discomfort at night but not during the day are both physiological and pathological. Physiological causes are irregular diet, eating stimulating food, etc., to regulate the main; pathological causes are reflux esophagitis, duodenal ulcer, gastric neurosis, etc., the treatment drugs are omeprazole, domperidone, etc.. 1. Physiological causes and treatment: such as irregular diet, eating stimulating food, etc. can affect the digestion and peristaltic function of the stomach, resulting in uncomfortable symptoms. The treatment is based on conditioning, such as regular and light diet, avoiding stimulating food, not eating before bedtime, and so on. 2. Pathological causes and treatment: such as reflux esophagitis can also have acid reflux, heartburn and other symptoms; such as duodenal ulcer can also have acid reflux, stomach pain when hungry and other symptoms; such as gastric neurosis can also have depression, anxiety and other mood changes. Commonly used drugs are omeprazole, domperidone, compound digestive enzymes, etc., sometimes also need to give anti-psychotics. As for the situation that the stomach is difficult at night but not during the day, it is recommended to actively consult the doctor to clarify the cause and then give corresponding treatment. The use of drugs should be under the guidance of a doctor.